Whole genome sequencing: Bioethics and clinical interpretation

I posted some documents that I could obtain permission for, as well as references for those that I could not..

-Gerry

Recommended reading:

[1] Dewey, F.E. et al.Clinical interpretation and implications of whole-genome sequencing. JAMA. 311(10):1035-1044 (2014)          doi:10.1001/jama.2014.1717.

[2] Jacob, H.J. et al. Genomics in clinical practice:Lessons from the front lines. Science Transl. Med. 5(194): 1-5 (2013).

[3] Ashley, Euan A., et al. Clinical assessment incorporating a personal genome. The Lancet 375(9725)1525-1535.(2010).

[4] Green, R, et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

      Genet.  Med. 15(7): 565-574 (2013).

[5] Brownstein, C. A. et al. An international effort towards developing  standards for best practices in analysis, interpretation     and reporting of clinical genome sequencing results in the CLARITY Challenge.Genome Biol.  2014, 15:R53.

[6] Landrum, Melissa J., et al. ClinVar: public archive of relationships among sequence variation and human phenotype.Nucleic     Acids. Res.42.D1: D980-D985 (2014).
 
[7] Lyon, G.J. et al. Exome sequencing and unrelated findings in the context of complex disease research: Ethical and clinical
 
      implications. Discovery Med. 12(62),:41 (2011).
 
 

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